lFollicular cells express factors which
recruit osteoclasts that permit bone remodeling around the erupting tooth.
lEvidences:
lIn osteopetrotic animals (which lack osteoclast differentiation), eruption is prevented
lImmunohistochemical findings of cellular activity around REE and dental follicle
lExperiment
lMolar removed, follicle stripped, molar
replaced – no
eruption
lCrown removed, follicle intact – eruptive
pathway still forms
within bone